Type:
Conference Paper›Invited and refereed articles in conference proceedings
Authored by:
Kyrtsos, C Rose., Baras, John S.
Conference date:
August 1-3, 2011
Conference:
ACM Conference on Bioinformatics, Computational Biology and Biomedicine 2011
Full Text Paper:
Abstract:
A simplified network describing the interactions between the cholesterol and beta amyloid (Aβ) synthesis pathways was generated using information available from literature and the KEGG database. A system of non-linear differential equations was developed and modeled using several different initial conditions. Rate constants were approximated using ratio-metric data from the literature, or by fitting parameters to obtain a stable simulation within given biological constraints. Simulations demonstrated the importance of negative feedback control by cholesterol in the regulation of beta-amyloid levels. Additionally, the effect of reduced LRP-1 levels and oscillatory cholesterol generation was studied.