@conference {
	title = {A systems biology model studying the role of cholesterol in Alzheimer{\textquoteright}s disease progression},
	author = {Kyrtsos, C Rose., Baras, John S.},
	year = {2011},
	month = {08/2011},
	abstract = {A simplified network describing the interactions between the cholesterol and beta amyloid (Aβ) synthesis pathways was generated using information available from literature and the KEGG database.~ A system of non-linear differential equations was developed and modeled using several different initial conditions.~ Rate constants were approximated using ratio-metric data from the literature, or by fitting parameters to obtain a stable simulation within given biological constraints.~ Simulations demonstrated the importance of negative feedback control by cholesterol in the regulation of beta-amyloid levels.~ Additionally, the effect of reduced LRP-1 levels and oscillatory cholesterol generation was studied.~},
	address = {Chicago, Illinois},
	booktitle = {ACM Conference on Bioinformatics, Computational Biology and~Biomedicine 2011}
}
