Type:
Conference Paper›Invited and refereed articles in conference proceedings
Authored by:
Kyrtsos, C Rose., Baras, John S.
Conference date:
August 7-10, 2012
Conference:
SIAM Conference on the Life Sciences 2012
Abstract:
Alzheimer's disease (AD) is the most common form of dementia affecting the elderly, leading to debilitating memory loss and significant cognitive decline. The exact mechanism of pathogenesis is not well understood. Here, we present an organ level model that studies the role of cholesterol metabolism and inflammation in the early stages of AD, demonstrating the importance of brain cholesterol on the expression of beta amyloid. The model has been further validated with experimental data.