@article {
	title = {Studying the Role of ApoE in Alzheimer{\textquoteright}s Disease Pathogenesis Using a Systems Biology Model},
	author = {Kyrtsos, C Rose., Baras, John S.},
	year = {2013},
	month = {10/2013},
	abstract = {Alzheimer{\textquoteright}s disease (AD) is the most common form of dementia. Even with its well-known symptoms of memory loss and well-characterized pathology of beta-amyloid (Aβ) plaques and neurofibrillary tangles, the disease pathogenesis and initiating factors are still not well understood. To tackle this problem, a systems biology model has been developed and used to study the varying e{\textregistered}ects of variations in the ApoE allele present, as well as the e{\textregistered}ects of short term and periodic inflammation at low to moderate levels. Simulations showed a late onset peak of Aβ~in the ApoE4 case that lead to localized neuron loss which could be ameliorated in part by application of short-term pro-inflammatory mediators. The model that has been developed herein represents one of the first attempts to model AD from a systems approach to study physiologically relevant parameters that may prove useful to physicians in the future.},
	pages = {pp. 1342003.1-1342003.21},
	volume = {Vol. 11},
	number = {Issue 5},
	journal = {Journal of Bioinformatics and Computational Biology (JBCB)}
}
